100 years of glucagon anniversary.

The year 2023 marks 100 years since publication of the first report of a hyperglycemic factor in pancreatic extracts which C P Kimball and John R Murlin named glucagon (from GLUCose AGONist). Glucagon has a range of profound effects on metabolism including, but not limited to, stimulation of hepatic glucose production. Dysregulation of glucagon secretion is a key feature of both major forms of diabetes, leading to the concept that diabetes is a bihormonal disorder. Still, the work to fully understand the production and biological effects of glucagon has proceeded at a slower pace compared to that of insulin. A recent resurgence of interest in the islet alpha (α) cell, the predominant site of glucagon production, has been facilitated in part by technological innovations. This work has led to significant developments in the field, from defining how alpha cells develop and how glucagon secretion from pancreatic alpha cells is regulated to determining the role of glucagon in metabolic homeostasis and the progression of both major forms of diabetes. In addition, glucagon is considered to be a promising target for diabetes therapy, with many new potential applications arising from research in this field. This collection of reviews, led by Guest Editors James Cantley, Vincent Poitout and Rebecca Hull-Meichle, is intended to capture the field's current understanding of glucagon and alpha cell biology, as well stimulate additional interest and research on this important hormone.

Preservação para a construção da Coleção Memória da Enfermagem na UNIRIO / Preservación para la construcción de la Colección Memoria de Enfermería en UNIRIO / Preservation for building Collection Memory of Nursing in UNIRIO

Objetivo: Mostrar os resultados do projeto de digitalização e publicação on-line dos acervos da Coleção Memória da Enfermagem (BSEN). Método: Foi realizada pesquisa do material bibliográfico existente no acervo, com as etapas de seleção, preparação dos itens, digitalização e publicação no catálogo on-line. Resultados: Criação da biblioteca digital da Coleção Memória da Enfermagem da UNIRIO. Conclusão: A digitalização dos acervos especiais é processo indispensável para a preservação da memória e disseminação da informação histórica

Objective: The study's goal has been to show the results of the digitization project and online publishing of Collection of Nursing Memory (BSEN). Methods: It is a research of existing bibliographical material that was held in the collection, with the stages of selection, preparation of items, digitization and publication in the catalog. Results: The creation of the digital library collection Memory Nursing - UNIRIO. Conclusion: The digitization of special collections is an essential process for the preservation of memory and dissemination of historical information

Objetivo: Mostrar los resultados de las colecciones de diseño y publicación en línea de escaneo de la colección Memoria de Enfermería (BSEN). Método: Investigación del material bibliográfico existente con las etapas de selección, preparación de artículos, la digitalización y publicación en el catálogo. Resultados: La creación de la biblioteca digital de la Colección Memoria de la Enfermería - UNIRIO. Conclusión: La digitalización de las colecciones especiales es un proceso esencial para la preservación de la memoria y la difusión de información histórica